Selenate-supplemented nutritional formula increases plasma selenium in hemodialysis patients
Identifieur interne : 000082 ( Main/Exploration ); précédent : 000081; suivant : 000083Selenate-supplemented nutritional formula increases plasma selenium in hemodialysis patients
Auteurs : Karla A. Temple [États-Unis] ; Anne M. Smith [États-Unis] ; David B. Cockram [États-Unis]Source :
- Journal of Renal Nutrition [ 1051-2276 ] ; 2000.
Abstract
Objective: The purpose of this study was to determine the short-term effect of feeding selenium-supplemented formulas on the selenium status of end-stage renal disease patients on hemodialysis. Design and setting: The prospective, randomized, single-blind study of parallel design was conducted at three hemodialysis clinics. Patients: A total of 79 hemodialysis patients were randomly assigned into one of three groups. Intervention: Liquid nutritional formula supplemented with either selenite (28 μg Se/8 oz, n = 26), selenate (28 μg Se/8 oz, n = 26), or nonfortified (7 μg Se/8 oz, n = 27) was fed to hemodialysis patients as their sole source of nutrition for 14 days. Main outcome measure: Plasma and red blood cell (RBC) selenium and glutathione peroxidase (GPX) activities were measured in predialysis blood both before (day 1) and after (day 8) a 7-day baseline period, and after subjects received the formula as the sole source of nutrition (approximately 35 kcal/kg/d) for 14 days (day 22). Results: Selenium intake (Mean ± SEM, μg/d) was 134 ± 9, 140 ± 9, and 35 ± 2 for patients receiving selenite-, selenate-, or non-supplemented formula, respectively. On day 22, plasma selenium (μmol/L) was greater (P < .032) in the selenate-supplemented group (1.5 ± 0.1) compared with the nonsupplemented group (1.2 ± 0.1), but not compared with the selenite-supplemented group (1.4 ± 0.1). Plasma GPX activity was 44% to 60% that of healthy controls and not different among groups. RBC selenium and GPX activities were within the normal range and were not different among groups. Conclusion: The results of this study indicate that a liquid formula supplemented with selenium as selenate is successful at maintaining selenium concentrations within normal range, as well as significantly increasing plasma selenium levels compared with nonsupplementation.
Url:
DOI: 10.1016/S1051-2276(00)90018-9
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Selenate-supplemented nutritional formula increases plasma selenium in hemodialysis patients</title><author><name sortKey="Temple, Karla A" sort="Temple, Karla A" uniqKey="Temple K" first="Karla A" last="Temple">Karla A. Temple</name></author><author><name sortKey="Smith, Anne M" sort="Smith, Anne M" uniqKey="Smith A" first="Anne M" last="Smith">Anne M. Smith</name></author><author><name sortKey="Cockram, David B" sort="Cockram, David B" uniqKey="Cockram D" first="David B" last="Cockram">David B. Cockram</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:29C3BBBBB991E3AC4D7CFA1471D5652154A09D1E</idno><date when="2000" year="2000">2000</date><idno type="doi">10.1016/S1051-2276(00)90018-9</idno><idno type="url">https://api.istex.fr/document/29C3BBBBB991E3AC4D7CFA1471D5652154A09D1E/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000213</idno><idno type="wicri:Area/Main/Curation">000189</idno><idno type="wicri:Area/Main/Exploration">000082</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Exploration">000082</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Selenate-supplemented nutritional formula increases plasma selenium in hemodialysis patients</title><author><name sortKey="Temple, Karla A" sort="Temple, Karla A" uniqKey="Temple K" first="Karla A" last="Temple">Karla A. Temple</name><affiliation wicri:level="4"><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Committee on Human Nutrition and Nutritional Biology, University of Chicago, Chicago, IL</wicri:regionArea><placeName><region type="state">Illinois</region><settlement type="city">Chicago</settlement></placeName><orgName type="university">Université de Chicago</orgName></affiliation></author><author><name sortKey="Smith, Anne M" sort="Smith, Anne M" uniqKey="Smith A" first="Anne M" last="Smith">Anne M. Smith</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Address reprint requests to Anne M. Smith, PhD, RD, Department of Human Nutrition and Food Management, The Ohio State University, 1787 Neil Ave, Columbus</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Human Nutrition and Food Management, The Ohio State University, Columbus, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Cockram, David B" sort="Cockram, David B" uniqKey="Cockram D" first="David B" last="Cockram">David B. Cockram</name><affiliation wicri:level="2"><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Medical Nutrition R & D, Ross Products Division, Abbott Laboratories, Columbus, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Renal Nutrition</title><title level="j" type="abbrev">YJREN</title><idno type="ISSN">1051-2276</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2000">2000</date><biblScope unit="volume">10</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="16">16</biblScope><biblScope unit="page" to="23">23</biblScope></imprint><idno type="ISSN">1051-2276</idno></series><idno type="istex">29C3BBBBB991E3AC4D7CFA1471D5652154A09D1E</idno><idno type="DOI">10.1016/S1051-2276(00)90018-9</idno><idno type="PII">S1051-2276(00)90018-9</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1051-2276</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective: The purpose of this study was to determine the short-term effect of feeding selenium-supplemented formulas on the selenium status of end-stage renal disease patients on hemodialysis. Design and setting: The prospective, randomized, single-blind study of parallel design was conducted at three hemodialysis clinics. Patients: A total of 79 hemodialysis patients were randomly assigned into one of three groups. Intervention: Liquid nutritional formula supplemented with either selenite (28 μg Se/8 oz, n = 26), selenate (28 μg Se/8 oz, n = 26), or nonfortified (7 μg Se/8 oz, n = 27) was fed to hemodialysis patients as their sole source of nutrition for 14 days. Main outcome measure: Plasma and red blood cell (RBC) selenium and glutathione peroxidase (GPX) activities were measured in predialysis blood both before (day 1) and after (day 8) a 7-day baseline period, and after subjects received the formula as the sole source of nutrition (approximately 35 kcal/kg/d) for 14 days (day 22). Results: Selenium intake (Mean ± SEM, μg/d) was 134 ± 9, 140 ± 9, and 35 ± 2 for patients receiving selenite-, selenate-, or non-supplemented formula, respectively. On day 22, plasma selenium (μmol/L) was greater (P < .032) in the selenate-supplemented group (1.5 ± 0.1) compared with the nonsupplemented group (1.2 ± 0.1), but not compared with the selenite-supplemented group (1.4 ± 0.1). Plasma GPX activity was 44% to 60% that of healthy controls and not different among groups. RBC selenium and GPX activities were within the normal range and were not different among groups. Conclusion: The results of this study indicate that a liquid formula supplemented with selenium as selenate is successful at maintaining selenium concentrations within normal range, as well as significantly increasing plasma selenium levels compared with nonsupplementation.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Illinois</li><li>Ohio</li></region><settlement><li>Chicago</li></settlement><orgName><li>Université de Chicago</li></orgName></list><tree><country name="États-Unis"><region name="Illinois"><name sortKey="Temple, Karla A" sort="Temple, Karla A" uniqKey="Temple K" first="Karla A" last="Temple">Karla A. Temple</name></region><name sortKey="Cockram, David B" sort="Cockram, David B" uniqKey="Cockram D" first="David B" last="Cockram">David B. Cockram</name><name sortKey="Smith, Anne M" sort="Smith, Anne M" uniqKey="Smith A" first="Anne M" last="Smith">Anne M. Smith</name><name sortKey="Smith, Anne M" sort="Smith, Anne M" uniqKey="Smith A" first="Anne M" last="Smith">Anne M. Smith</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Lorraine/explor/TlfNancyV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000082 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000082 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Lorraine
|area= TlfNancyV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:29C3BBBBB991E3AC4D7CFA1471D5652154A09D1E
|texte= Selenate-supplemented nutritional formula increases plasma selenium in hemodialysis patients
}}
| This area was generated with Dilib version V0.6.39. |  |